New technology developed by scientists can decode degenerative brain disorders

New labelling technology developed by South Korean scientists, called ‘NeuM’, allows detailed observation of neuronal structure to decode degenerative brain disorders like Alzheimer’s and Parkinson’s disease. The technology can monitor changes in nerve cells for up to 72 hours, providing real-time insights into neuronal changes.

The Korea Institute of Science and Technology (KIST) team behind NeuM stated that the technology works by selectively labelling neuronal membranes, visualising neuronal structures, and enabling real-time monitoring of neuronal changes. This is crucial for understanding how nerve cells change during diseases and in normal conditions, as they continuously transmit information from sensory organs to the brain.

Current gene-based and antibody-based labelling technologies face challenges with accuracy and long-term tracking of living neurons. NeuM addresses these issues with its molecular design of neuronal cells, offering excellent binding affinity to neuronal membranes for long-term tracking and high-resolution imaging of neurons. Dr. Kim Yun Kyung from KIST’s Brain Science Institute emphasized NeuM’s ability to distinguish ageing and degenerating neurons, aiding in the study of degenerative brain disorders and treatment development.

Looking ahead, the researchers plan to enhance NeuM for more precise neuron analysis by designing fluorescence wavelengths to differentiate colors like green and red. This advancement could further improve the technology’s capabilities in studying neuronal changes and understanding degenerative brain disorders.