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Drug touted by Trump linked to higher Covid death rates

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Drug touted by Trump linked to higher Covid death rates

The antimalarial drug being taken by US President Donald Trump has been linked with elevated rates of death and coronary heart issues in Covid-19 sufferers, in accordance to a examine revealed within the medical journal The Lancet

The examine’s authors really helpful that hydroxychloroquine, and the intently associated drug chloroquine, shouldn’t be used to deal with sufferers exterior of medical trials, as they discovered it didn’t profit folks affected by Covid-19 and will have critical unwanted effects. 

Mr Trump has hailed hydroxychloroquine as a “game-changer” for Covid-19 sufferers and performed down the dangers, as a result of the drug is already used to deal with malaria, lupus and arthritis. In early April, he praised the drug and requested: “What have you ever obtained to lose?” This week, he mentioned he was taking it as a safety measure in opposition to the illness. 

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Mandeep Mehra, lead writer of the examine and govt director of the Brigham and Girls’s Hospital Middle for Superior Coronary heart Illness, mentioned randomised medical trials shall be important to affirm the hurt or advantages of the remedies. 

“That is the primary large-scale examine to discover statistically strong proof that remedy with chloroquine or hydroxychloroquine doesn’t profit sufferers with Covid-19. As a substitute, our findings counsel it might be related to an elevated threat of significant coronary heart issues and elevated threat of death,” he mentioned. 

The US Meals and Drug Administration warned late final month that there have been stories of significant coronary heart rhythm issues in sufferers taking the drug and suggested medical doctors not to prescribe it exterior of a hospital. 

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The brand new examine analysed information from nearly 15,000 Covid-19 sufferers receiving a mixture of 4 drug regimens and in contrast it with a management group of 81,000. 

On the finish of the examine, a higher proportion of individuals had died within the teams on remedy than amongst those that weren’t on the medication. About one in six sufferers on hydroxychloroquine or chloroquine alone had died. When taken with an antibiotic, death rates rose to one in 4 for hydroxychloroquine and one in 5 for chloroquine. This in contrast with a death charge within the management group of 1 in 11. 

The researchers cautioned that among the distinction within the rates of mortality was due to underlying variations between sufferers who acquired the remedies and people who didn’t, as a result of this was not a randomised medical trial. 

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However even after accounting for variations in age, race, and pre-existing situations similar to coronary heart illness and diabetes, they discovered the medication had been related to an elevated threat of death. Sufferers taking hydroxychloroquine with the antibiotic noticed a fivefold improve within the threat of creating a critical coronary heart arrhythmia, even accounting for underlying well being situations and demographic variations.

The trial enrolled some sufferers within the US, the place the drug has an emergency use authorisation to be used in opposition to Covid-19.

“While you take a look at the suggestions given by regulatory authorities all around the world, what else did they’ve on the time?” mentioned Frank Ruschitzka, head of cardiology at College Hospital Zurich and a co-author on the examine. “In mild of this new information, I hope they are going to rethink a few of these suggestions. We won’t depend on anecdotal proof, whoever it is coming from. Please depend on the science. Let the information communicate.”

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Christian Funck-Brentano, a professor on the Sorbonne College, who was not concerned within the examine, wrote a remark article about it for The Lancet.

He mentioned: “This well-conducted observational examine provides to preliminary stories suggesting that chloroquine, hydroxychloroquine, alone or with [the antibiotic] azithromycin is just not helpful and could also be dangerous in hospitalised Covid-19 sufferers.”

(Notice: It is a Article Robotically Generated Via Syndication, Right here is The Unique Source Written by [author_name])

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Sundar Pichai Net Worth 2024: How Much is the CEO of Google Worth?

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Sundar Pichai Net Worth 2024: How Much is the CEO of Google Worth?

Who is Sundar Pichai?

Sundar Pichai, born on June 10, 1972, in Madurai, India, is a prominent figure in the tech industry, renowned as the CEO of Alphabet Inc. and its subsidiary Google LLC. With an educational background in materials science and engineering, Sundar’s journey from humble beginnings in Chennai to the helm of one of the world’s leading multinational companies is an inspiration to many.

Sundar Pichai Career

Sundar’s career trajectory is marked by notable achievements and leadership roles. Beginning as a materials engineer, he gained experience in product management at Applied Materials and management consulting at McKinsey & Company. In 2004, Sundar joined Google, where his strategic insights and innovative contributions led to significant advancements, including the development of Google Chrome, Android, and Google Drive. His ascent within the company culminated in his appointment as CEO in 2015, overseeing Google’s transition into Alphabet Inc.

Sundar Pichai’s Net Worth

As of 2024, Sundar Pichai’s net worth is estimated to exceed $1.66 Billion, primarily attributed to his role as CEO of Alphabet Inc. and his ownership of approximately 520,668 shares of Alphabet Inc. stock. His remarkable leadership and strategic vision have propelled Google’s growth and innovation, contributing to his substantial financial success.

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Sundar Pichai Age

As of 2023, Sundar Pichai is 50 years old, having been born on June 10, 1972.

Sundar Pichai Family: Wife and Children

Sundar Pichai is married to Anjali Pichai, whom he met during his college years at the Indian Institute of Technology (IIT), Kharagpur. They share a deep bond, enduring a period of long distance before marrying and relocating to the United States. Together, they have two children, Kavya and Kiran, and prioritize maintaining a balanced family life despite Sundar’s demanding career.

Sundar Pichai Height and Weight

Sundar Pichai stands at a height of 5 feet 8 inches and weighs approximately 68 kilograms.

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Also Read: Eric Eisner Net Worth 2024: How Much is the Film Producer Worth?

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Important Ripple V. SEC Lawsuit Update: Parties Cross Swords Over A Key Witness Testimony

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The legal wrangling between Ripple and the US Securities and Exchange Commission (SEC) is becoming increasingly acrimonious. Despite the crypto sector eagerly awaiting an outcome, the case grows more complicated with each passing day.

In a recent move, the SEC filed its opposition to Ripple’s motion to strike new expert materials, including a testimony known as the ‘Fox Declaration,’ which Ripple claimed represents unsolicited expert opinion.

However, the SEC countered this argument, stating that it was a common process akin to standard summary evidence in support of calculations for disgorgement.

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The SEC insisted, ‘It’s not an expert report, does not rely on specialized experience, and does not render any opinions at all, let alone an “expert” one. Nor does it present the testimony of a percipient witness. Rather, it applies basic arithmetic to Ripple’s financial records to streamline the presentation of evidence to Judge Torres… The court should deny Ripple’s motion.’

The SEC also said that the ‘Fox Declaration’ consists of information derived from Ripple’s own documents, including tax returns and financial statements, which can be useful for determining the case’s outcome. The SEC also reminded that this very argument was already struck down by Federal Judge Torres earlier.

XRP Lawsuit: Whales Shift 74M XRP Amid Approaching SEC Deadline, What’s Next?

Just before the SEC’s deadline in the Ripple lawsuit, there was significant whale activity, with transactions affecting over 74 million XRP, leading to increased speculation about the motive behind this move. However, XRP prices have taken a hit, more due to a global crypto market sell-off and significant whale movements. Later in the day, the SEC is expected to file its reply in the Ripple case.

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It was an eventful day, with major crypto assets facing the heat and values tanking. XRP prices have dropped by 4%, but major whale activity involving significant transfers of XRP, totaling $15.92 million to Bitstamp by unidentified whales, has experts talking and wondering about the real motive behind this action. Coupled with the uncertainties around the ongoing legal battle between Ripple Labs and the U.S. Securities and Exchange Commission (SEC), the future of the crypto sector hangs in balance with the final result of this legal wrangling.

Also Read: Philips Settles for $1.1 Billion Over Sleep Apnea Device Recall Linked to Cancer Risks

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Philips Settles for $1.1 Billion Over Sleep Apnea Device Recall Linked to Cancer Risks

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Dutch conglomerate Philips has concluded a $1.1 billion deal to resolve claims in the United States related to the recall of more than 1 million breathing machines. These devices, also known as sleep apnea devices, were recalled in 2021 due to concerns that they posed a potential cancer risk.

Philips had recalled millions of its CPAP machines from the market after concerns arose that components used in the device, especially the foam, could enter the airways and potentially cause cancer. The recall occurred in 2021, and further sales of the devices were halted. The money from the deal will cover injury claims for 58,000 people, earmarking $1.075 billion for a personal injury settlement and $25 million for medical monitoring.

Lawyers representing the plaintiffs stated,

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“Ultimately, these combined agreements accomplish what we sought to achieve when this litigation began — holding Philips accountable by obtaining care for those with physical injuries and compensation for those needing new respiratory devices.”

CPAP machines, an acronym for continuous positive airway pressure machines, are used to treat sleep apnea, a serious sleep disorder where a person’s breathing is obstructed during sleep. This can be caused by the throat muscles obstructing the airways, brain disorders, or unknown causes. CPAP machines help restore the air supply via a mask and keep the airways open.

An estimated 33 million Americans use CPAP machines to treat the symptoms of sleep apnea, according to figures released by the National Council on Aging. Untreated sleep apnea can lead to several complications, including higher risks of developing diabetes, hypertension, and heart diseases.

Some customers alleged that Philips’ DreamStation machines, which were then the brand leader, had been expelling gas and bits of foam into their lungs. Philips made no admission of fault in its products and stated that most of the claims were related to “alleged technical malfunctions” that did not involve any serious injury or death. However, Chief Executive Roy Jakobs said in a statement on Monday that the company is genuinely concerned with any discomfort the patients may have experienced.

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Philips is facing a number of litigations in the US and is effectively out of the sleep machines and ventilators market, with its presence limited to selling replacement parts and servicing the machines that already exist in hospitals and patients’ homes. Earlier this year, Philips agreed to a decree requiring it to halt the sale of its devices in the US until certain conditions are met. It also agreed to repair and replace the more than 1 million breathing machines currently used by patients in the US.

What can consumers do?

The settlement, which must be approved by a judge, entitles users to a $100 award if they return their recalled device by August 9, 2024 — the claim deadline. Users who believe their device is defective should act soon to verify this if they haven’t already, and Philips’ recall page offers ways to check serial numbers and register a product. A dedicated website is available which accepts claims for the financial-loss settlement. Payments tied to the settlement are expected to be completed by 2025.

The news has been welcomed in the share markets, and Royal Philips NV shares soared nearly 30 percent in Amsterdam since the settlement amount is much less than what was expected.

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Also Read: Gerber and Perrigo Face New Lawsuit Over ‘Store-Brand’ Infant Formula Pricing; All Pending Toxic Baby Food Cases Consolidated into New Class Action MDL

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